Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr

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Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr

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All Suite 100% Non Smoking Hotel walking distance to Shea's, Buffalo Bison's and First Niagara Center Explore & More - Ralph C. Wilson Jr.
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We welcome you to stay at our Holiday Inn Express & Suites Buffalo, located in the heart of downtown near Roswell Park, John R. Oishei Children's Hospital, Buffalo General Hospital, Convention Center and Canalside. Hotel parking is offsite and available nearby at additional charge in parking garage. Enjoy being nestled in the heart of the Theatre District, where you can experience a grand performance at Shea's Performing Arts Center or the Irish Classical Theatre. Take in a concert at the Town Ballroom or TRALF located within the same block or hop on the above ground trolley train to the Key Bank Center. Children's Museum and the Naval Park are also just a few blocks away. The city is also packed with events and festivals at Canalside and Sahlen's Field. Admire contemporary art at the Albright-Knox Art Gallery or discover Frank Lloyd Wright's stunning residencies nearby and marvel at the Darwin Martin House. Don't forget to make the 20 mile trip to one of the Nation's North American Wonders of the World - Niagara Falls! For those traveling on business we are in close proximity to M&T Bank, Buffalo Niagara Medical Campus, and New Era Cap. You will appreciate our 24-hour Business Center and Fitness Center.

10/29/2026

Lobby looks good. Stay feels even better. 💚

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09/29/2026

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09/24/2026

Stepping into vacation, one easy moment at a time 🌴✨

At Holiday Inn Resort by IHG, the only plan is to take it slow and enjoy the stay.

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Address

601 Main Street
Buffalo, NY
14203

Website

https://www.ihg.com/holidayinnexpress/hotels/us/en/buffalo/bufms/hoteldetail?cm_mmc=FacebookMaps-_-EX-_-US-_-BUFMS

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