Holiday Inn Express & Suites Sikeston

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Holiday Inn Express & Suites Sikeston Holiday Inn Express - Stay Smart. Large illuminating lights and contemporary decor welcome you to the Holiday Inn Express & Suites Sikeston.

Our hotel’s address in Sikeston, MO surrounds you with fun and nearby attractions. Thanks to a convenient location close to I55,I60 and nearby companies, including, Monsanto, Cargill, and Siemens, John Deere, Orgill, Tyson, Unilever and Sikeston Power Plant. In addition, we provide guests with a selection of handy services at our state of the art Business Center. Sikeston is also home to the annual Sikeston Jaycee Bootheel Rodeo, which draws large crowds every August. Our accommodations are close to shops and dining venues. Whether you’re staying in Sikeston, MO for business or pleasure, we have the amenities to satisfy your needs. Connecting to colleagues and family is easy with the free high speed Internet access, and mornings are great with a cup of fresh coffee and gooey cinnamon roll from our complimentary, hot Express Start breakfast bar. Go for a dip in the indoor heated pool or burn calories in our state of the art Fitness Center. If you are looking for lodging in Sikeston, MO, our hotel is the smart choice.

10/30/2026

We'll just drop this right here.

*Offerings vary by region.

With bacon this good, we’d never.  *Offerings vary by region.
10/26/2026

With bacon this good, we’d never.

*Offerings vary by region.

10/20/2026

Sweet, savory, stackable, spoonable… wherever you wake up, there’s something tasty to get out of bed for.

A stay that loves your to-do AND your do-not-disturb.
10/15/2026

A stay that loves your to-do AND your do-not-disturb.

10/06/2026

A winning blend: Costa Coffee and Holiday Inn Express.

09/29/2026

Morning motivation comes standard: Free hot breakfast and Costa Coffee at Holiday Inn Express.

*Offerings vary by region.

09/25/2026

Keep rolling, we’ve got you covered. Everything you need to rest, recharge, and fuel up is ready at Holiday Inn Express by IHG.

09/23/2026

We saved you a spot. It’s next to the cinnamon rolls.

*Offerings vary by region.

09/21/2026

*Books stay for breakfast*

*Offerings vary by region.

It's love at first sip.  *Offerings vary by region.
09/19/2026

It's love at first sip.

*Offerings vary by region.

09/17/2026

Game day’s sweetest start.

*Offerings vary by region.

Address

115 Hospitality Drive
Sikeston, MO
63801

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